Donald A. McClain

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

Christine M. Kusminski, William L. Holland, Kai Sun et al. · Nature Medicine · 2012 · 470 citations

Obesity, Metabolic Syndrome, Mitochondrial Function +14

A genetic mechanism for Tibetan high-altitude adaptation

Felipe Lorenzo, Chad D. Huff, Mikko Myllymäki et al. · Nature Genetics · 2014 · 428 citations · Full text

Molecular Ecology, Fitness, Medicine +9

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

Donald A. McClain, Hiroshi Maegawa, J Lee et al. · Journal of Biological Chemistry · 1987 · 405 citations · Full text

Insulin Signaling, Receptor Tyrosine Kinase, Endocytic Pathway +21

Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

Darrell D. Belke, Sandrine Bétuing, Martin J. Tuttle et al. · Journal of Clinical Investigation · 2002 · 375 citations · Full text

Cardiac Muscle, Metabolic Remodeling, Insulin Signaling +21

Functionally distinct insulin receptors generated by tissue-specific alternative splicing.

Luitgard Mosthaf, K A Grako, Thomas J. Dull et al. · The EMBO Journal · 1990 · 357 citations · Full text

Molecular Physiology, Signal Transduction, Distinct Insulin Receptors +5