Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Kazuki Yasuda, Kazuaki Miyake, Yukio Horikawa, +43

Nature Genetics

Genetic DeterminantAutoimmune DiseaseGeneticsDiabetesImmunology +5

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

Ko Kotani, Wataru Ogawa, Michihiro Matsumoto, +8

Molecular and Cellular Biology

Akt ActivationGlucose UptakeInsulin SignalingPkclambda PathwayCell Signaling +16

PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

Michihiro Matsumoto, Wataru Ogawa, Kazunori Akimoto, +12

Journal of Clinical Investigation

PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

Michihiro Matsumoto, Wataru Ogawa, Kazunori Akimoto, +12

Journal of Clinical Investigation

Replication of Genome-Wide Association Studies of Type 2 Diabetes Susceptibility in Japan

Yukio Horikawa, Kazuaki Miyake, Kazuki Yasuda, +15

The Journal of Clinical Endocrinology & Metabolism

Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver

Kazuaki Miyake, Wataru Ogawa, Michihiro Matsumoto, +3

Journal of Clinical Investigation

Phosphoinositide 3-Kinase SignalingPathologyHyperlipidemiaInsulin SignalingOxidative Stress +24

Role of the Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase Signaling Pathway in Insulin-Induced Expression of Sterol Regulatory Element Binding Protein 1c and Glucokinase Genes in Rat Hepatocytes

Michihiro Matsumoto, Wataru Ogawa, Kiyoshi Teshigawara, +4

Diabetes

Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-Wide Association Studies

M. Geoffrey Hayes, Anna Pluzhnikov, Kazuaki Miyake, +9

Diabetes

Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver

Kazuaki Miyake, Wataru Ogawa, Michihiro Matsumoto, +3

Journal of Clinical Investigation

Phosphoinositide 3-Kinase SignalingPathologyHyperlipidemiaInsulin SignalingOxidative Stress +25

Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, +20

Journal of Human Genetics

Metabolic SyndromeGenetic DeterminantTcf7l2 PolymorphismsDiabetes EpidemiologyDiabetes +6