Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Qin Yang, Timothy E. Graham, Nimesh Mody, +6

Nature

ObesityMetabolic SyndromeSignal TransductionMetabolic DisorderBiochemistry +8

Insulin-Induced Phosphorylation and Activation of Cyclic Nucleotide Phosphodiesterase 3B by the Serine-Threonine Kinase Akt

Tadahiro Kitamura, Yukari Kitamura, Shoji Kuroda, +8

Molecular and Cellular Biology

Serine-threonine Kinase AktMouse Pde3bSignal TransductionMolecular PhysiologyBiochemistry +13

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

Ko Kotani, Wataru Ogawa, Michihiro Matsumoto, +8

Molecular and Cellular Biology

Akt ActivationGlucose UptakeInsulin SignalingPkclambda PathwayCell Signaling +16

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle

Eugénia Carvalho, Ko Kotani, Odile D. Peroni, +1

American Journal of Physiology-Endocrinology and Metabolism

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

Tohru Uchida, Takehiro Nakamura, Naoko Hashimoto, +8

Nature Medicine

Metabolic SyndromeInsulin SignalingDiabetes ManagementSignal TransductionPhysiology +11

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

Jason K. Kim, Ariel Zisman, Jonathan J. Fillmore, +8

Journal of Clinical Investigation

Insulin-Stimulated Protein Kinase C λ/ζ Activity Is Reduced in Skeletal Muscle of Humans With Obesity and Type 2 Diabetes

Young‐Bum Kim, Ko Kotani, Theodore P. Ciaraldi, +2

Diabetes

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization

Ko Kotani, Odile D. Peroni, Yasuhiko Minokoshi, +2

Journal of Clinical Investigation

NutritionCritical DefectInsulin SignalingObesityMetabolic Syndrome +15

Dok1 mediates high-fat diet–induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation

Tetsuya Hosooka, Tetsuya Noguchi, Ko Kotani, +13

Nature Medicine

Ppar-γ PhosphorylationMetabolic DisorderAdipokinesInsulin SignalingObesity +14

Phosphoinositide 3-Kinase Is Required for Insulin-Induced but Not for Growth Hormone- or Hyperosmolarity-Induced Glucose Uptake in 3T3-L1 Adipocytes

Hiroshi Sakaue, Wataru Ogawa, Masafumi Takata, +7

Molecular Endocrinology