Martina Rupertová

The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine<b><i>N</i></b>2-Oxide

Marie Stiborová, Jan Sejbal, Lucie Bořek-Dohalská et al. · Cancer Research · 2004 · 133 citations

Medicine, Biochemistry, Pharmacology +11

Cytochrome <i>b</i>₅ Increases Cytochrome P450 3A4-Mediated Activation of Anticancer Drug Ellipticine to 13-Hydroxyellipticine Whose Covalent Binding to DNA Is Elevated by Sulfotransferases and <i>N</i>,<i>O</i>-Acetyltransferases

Marie Stiborová, Radek Indra, Michaela Moserová et al. · Chemical Research in Toxicology · 2012 · 36 citations

Medicine, Biochemistry, Pharmacology +17

Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems.

Marie Stiborová, Lucie Bořek-Dohalská, Dagmar Aimová et al. · PubMed · 2006 · 33 citations

Medicine, Biochemistry, Pharmacology +15

Formation and persistence of DNA adducts of anticancer drug ellipticine in rats

Marie Stiborová, Martina Rupertová, Dagmar Aimová et al. · Toxicology · 2007 · 31 citations

Pharmacy, Biochemistry, Pharmacology +11