Alan W. Muir

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 457 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie · 2002 · 226 citations

Medicine, Neuroscience, Pharmacology +10

EFFECTS OF A NEW NEUROMUSCULAR BLOCKING AGENT (ORG 9426) IN ANAESTHETIZED CATS AND PIGS AND IN ISOLATED NERVE-MUSCLE PREPARATIONS

Alan W. Muir, James T Houston, K.L. GREEN et al. · British Journal of Anaesthesia · 1989 · 101 citations · Full text

Veterinary Medicine, Veterinary Anesthesiology, Veterinary Pharmacology +10

DEVELOPMENT OF A SEVERE MODEL OF EARLY CORONARY ARTERY LIGATION‐INDUCED DYSRHYTHMIAS IN THE ANAESTHETIZED RAT

Richard Marshall, Alan W. Muir, E. Winslow · British Journal of Pharmacology · 1981 · 56 citations · Full text

Medicine, Cardiology, Pharmacology +12

THE BENEFICIAL ACTIONS OF BEPRIDIL IN ACUTE MYOCARDIAL INFARCTION IN ANAESTHETIZED DOGS

Richard Marshall, Alan W. Muir · British Journal of Pharmacology · 1981 · 37 citations · Full text

Medicine, Cardiology, Pharmacology +17