Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy

Peter S. Dragovich, Thomas H. Pillow, Robert A. Blake, +34

Journal of Medicinal Chemistry

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA <i>In Silico</i> Strategy

Zhihua Li, Gary R. Mirams, Takashi Yoshinaga, +39

Clinical Pharmacology & Therapeutics

Towards in vitro models for reducing or replacing the use of animals in drug testing

David M. Stresser, Anna K. Kopec, Philip Hewitt, +24

Nature Biomedical Engineering

Animal TestingXenotransplantationPreclinical Drug EvaluationVitro ModelsPharmacology +9

Drug‐induced allergic hepatitis develops in mice when myeloid‐derived suppressor cells are depleted prior to halothane treatment

Mala Chakraborty, Aaron Fullerton, Kenrick Semple, +10

Hepatology

A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma

Satoko Kakiuchi-Kiyota, Thorsten Ross, Heidi Ackerly Wallweber, +27

Leukemia

Hematological MalignancyTumor BiologyMalignant Blood DisorderImmunologyMultiple Myeloma +5

Natural Killer Cells Mediate Severe Liver Injury in a Murine Model of Halothane Hepatitis

Christine M. Dugan, Aaron Fullerton, Robert A. Roth, +1

Toxicological Sciences

Molecular Mechanisms of Hepatocellular Apoptosis Induced by Trovafloxacin-Tumor Necrosis Factor-alpha Interaction

Kevin M. Beggs, Aaron Fullerton, Kazuhisa Miyakawa, +2

Toxicological Sciences

The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability

Patrick J. Shaw, Aaron Fullerton, Michael A. Scott, +2

Toxicology and Applied Pharmacology

InflammationIdiosyncratic LiabilityHepatologyMedicineLiver Physiology +9

Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related

Kevin M. Beggs, Ashley R. Maiuri, Aaron Fullerton, +4

Toxicology

InflammationSignaling PathwayAutoimmune DiseaseHepg2 CellsApoptosis +11

Oral administration of irinotecan in patients with solid tumors: an open-label, phase I, dose escalating study evaluating safety, tolerability and pharmacokinetics

Iben Kümler, Peter G. Sørensen, Jesper Andreas Palshof, +7

Cancer Chemotherapy and Pharmacology