Mark J. Crabtree

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

Jade Bailey, Marina Diotallevi, T. NICOL et al. · Cell Reports · 2019 · 248 citations · Full text

Prevention and Reversal of Premature Endothelial Cell Senescence and Vasculopathy in Obesity-Induced Diabetes by Ebselen

Sergey V. Brodsky, Olga Gealekman, Jun Chen et al. · Circulation Research · 2003 · 209 citations

Lipid Peroxidation, Oxidative Stress, Obesity +18

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling

Mark J. Crabtree, Amy L. Tatham, Ashley Hale et al. · Journal of Biological Chemistry · 2009 · 208 citations · Full text

Aldo-keto Reductase, Dhfr Inhibition, Molecular Biology +19

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS

Mark J. Crabtree, Caroline L. Smith, George Lam et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2008 · 206 citations · Full text

Endothelial Cells, Nitric Oxide, No Insufficiency +17

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

Mark J. Crabtree, Amy L. Tatham, Yasir Al-Wakeel et al. · Journal of Biological Chemistry · 2008 · 191 citations · Full text

Biopterin Redox Status, Tetrahydrobiopterin-enos Stoichiometry, Redox Biology +20