Yun-Chou Tan

Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2<i>H</i>-pyran-4-ylamino)pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

David Goldstein, Michael Soth, Tobias Gabriel et al. · Journal of Medicinal Chemistry · 2011 · 74 citations · Full text

Pharmacotherapy, New Series, System Pharmacology +21

Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors

Fernando Padilla, Niala Bhagirath, Shaoqing Chen et al. · Journal of Medicinal Chemistry · 2013 · 39 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +12

Discovery of potent and bioavailable GSK-3β inhibitors

Leyi Gong, Don Hirschfeld, Yun-Chou Tan et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 30 citations · Full text

Medicinal Chemistry, Bioavailable Gsk-3β Inhibitors, Medicine +5

Discovery of <i>N</i>-[4-[6-<i>tert</i>-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1<i>H</i>-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase

Francisco X. Talamás, Sarah C. Abbot, Shalini Anand et al. · Journal of Medicinal Chemistry · 2013 · 30 citations · Full text

Quinoline 41, Bioorganic Chemistry, Viral Polymerase Structure +17

Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead

Wylie S. Palmer, Muzaffar Alam, Humberto Arzeno et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 25 citations · Full text

Amino-pyrimidine Inhibitors, Medicinal Chemistry, Pharmaceutical Chemistry +12