Hong Ouyang

Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator

Onofrio Laselva, Claire Bartlett, T. Gunawardena et al. · European Respiratory Journal · 2020 · 164 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15

Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue

Steven V. Molinski, Saumel Ahmadi, Wan Ip et al. · EMBO Molecular Medicine · 2017 · 105 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Heat shock protein hsp70 accelerates the recovery of heat-shocked mammalian cells through its modulation of heat shock transcription factor HSF1.

D Kim, Hong Ouyang, G C Li · Proceedings of the National Academy of Sciences · 1995 · 96 citations · Full text

Life Sciences, Immunology, Cell Signaling +9

Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia

Saumel Ahmadi, Zoltán Bozóky, Michelle Di Paola et al. · npj Genomic Medicine · 2017 · 89 citations · Full text

Medicine, Molecular Medicine, Pharmacology +15

Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action

Onofrio Laselva, Paul D. W. Eckford, Claire Bartlett et al. · Journal of Cystic Fibrosis · 2019 · 70 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15