Onofrio Laselva

Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator

Onofrio Laselva, Claire Bartlett, T. Gunawardena et al. · European Respiratory Journal · 2020 · 162 citations · Full text

Genetics, Molecular Biology, Pathology +18

<scp>O</scp> rkambi® and amplifier co‐therapy improves function from a rare <i> <scp>CFTR</scp> </i> mutation in gene‐edited cells and patient tissue

Steven V. Molinski, Saumel Ahmadi, Wan Ip et al. · EMBO Molecular Medicine · 2017 · 105 citations · Full text

Functional rescue of c.3846G&gt;A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action

Onofrio Laselva, Paul D. W. Eckford, Claire Bartlett et al. · Journal of Cystic Fibrosis · 2019 · 68 citations · Full text

Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site

Steven V. Molinski, Vijay Shahani, Adithya S. Subramanian et al. · Proteins Structure Function and Bioinformatics · 2018 · 60 citations

Structural Bioinformatics, Biomolecular Structure Prediction, Genetics +18

Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains

Onofrio Laselva, Steven V. Molinski, Valeria Casavola et al. · Molecular Pharmacology · 2018 · 58 citations · Full text