Onofrio Laselva - Concepedia

Author

Onofrio Laselva

Hospital for Sick Children ORCID

Also Known As

LASELVA, ONOFRIO, Lopes-Pacheco, Miquéias, O Laselva, O. Laselva, Onofrio Laselva

Publications

1.5K

Citations

H-Index

Concepts

All Affiliations

Hospital for Sick Children University of Toronto University of Foggia University of Bari Aldo Moro University Health Network

About

Onofrio Laselva is an author at Hospital for Sick Children specializing in medicine, cell biology, and cellular physiology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	11	12	522
2	Natural Sciences	5	5	290
3	Biochemistry	3	3	100
4	Engineering	2	2	55
5	Health Sciences	2	2	70

Onofrio Laselva

Publications

1.4K

Citations

H-Index

Page 1

	Year	Citations
Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator Onofrio Laselva, Claire Bartlett, T. Gunawardena, European Respiratory Journal GeneticsMolecular BiologyPathologyMolecular GeneticsCellular Physiology	2020	162
<scp>O</scp> rkambi® and amplifier co‐therapy improves function from a rare <i> <scp>CFTR</scp> </i> mutation in gene‐edited cells and patient tissue Steven V. Molinski, Saumel Ahmadi, Wan Ip, EMBO Molecular Medicine	2017	105
Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action Onofrio Laselva, Paul D. W. Eckford, Claire Bartlett, Journal of Cystic Fibrosis	2019	68
Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site Steven V. Molinski, Vijay Shahani, Adithya S. Subramanian, Proteins Structure Function and Bioinformatics Structural BioinformaticsBiomolecular Structure PredictionGeneticsMolecular BiologyCytoskeleton	2018	60
Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains Onofrio Laselva, Steven V. Molinski, Valeria Casavola, Molecular Pharmacology	2018	58
ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel Yu-Sheng Wu, Janet Jiang, Saumel Ahmadi, Molecular Pharmacology	2019	51
Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator Onofrio Laselva, Zafar Qureshi, Zhiwei Zeng, iScience Proteinlipid InteractionProtein SecretionMolecular BiologyCellular PhysiologyMembrane Transport	2021	51
Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells Maria Favia, Maria Teresa Mancini, Valentino Bezzerri, American Journal of Physiology-Lung Cellular and Molecular Physiology	2014	48
Generation of functional ciliated cholangiocytes from human pluripotent stem cells Mina Ogawa, Jiaxin Jiang, Sunny Xia, Nature Communications Adult Stem CellImmunologyBile Duct FunctionCholangiopathiesCellular Physiology	2021	44
Correctors of mutant CFTR enhance subcortical cAMP–PKA signaling through modulating ezrin phosphorylation and cytoskeleton organization Anna Claudia Abbattiscianni, Maria Favia, Maria Teresa Mancini, Journal of Cell Science	2016	42

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