Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

Sina Haftchenary, H. Artee Luchman, Andriana O. Jouk, +13

ACS Medicinal Chemistry Letters

High-grade GliomasTreating GlioblastomaCancer BiologyGliomaTumor Biology +19

Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities

Steven Fletcher, Jardeep Singh, Xiaolei Zhang, +8

ChemBioChem

Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site

Steven V. Molinski, Vijay Shahani, Adithya S. Subramanian, +7

Proteins Structure Function and Bioinformatics

Structural BioinformaticsBiomolecular Structure PredictionGeneticsMolecular BiologyCytoskeleton +16

Concise access to N9-mono-, N2-mono- and N2,N9-di-substituted guanines via efficient Mitsunobu reactions

Steven Fletcher, Vijay Shahani, Alan J. Lough, +1

Tetrahedron

Cross-coupling ReactionEngineeringN9-di-substituted GuaninesOrganic ChemistryConcise Access +4

Identification of NAE Inhibitors Exhibiting Potent Activity in Leukemia Cells: Exploring the Structural Determinants of NAE Specificity

Julie L. Lukkarila, Sara R. da Silva, Mohsin Ali, +7

ACS Medicinal Chemistry Letters

Molecular BiologyLeukemia CellsPharmaceutical ChemistryMedicinal ChemistryStructural Determinants +14

Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies

Vijay Shahani, Peibin Yue, Sina Haftchenary, +7

ACS Medicinal Chemistry Letters

Drug TargetMolecular BiologyPharmacotherapyTumor BiologySystems Pharmacology +23

Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein

Vijay Shahani, Peibin Yue, Steven Fletcher, +9

Bioorganic & Medicinal Chemistry

Vitro CharacterizationBiochemistryMedicineNatural SciencesPeptoid +6

Facile and efficient access to 2,6,9-tri-substituted purines through sequential N9, N2 Mitsunobu reactions

Steven Fletcher, Vijay Shahani, Patrick T. Gunning

Tetrahedron Letters

Combinatorial ChemistryDiversity Oriented SynthesisEngineeringNatural SciencesDiversity-oriented Synthesis +7

Discovery of a Novel DCAF1 Ligand Using a Drug–Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets

Serah Kimani, Julie Owen, Stuart R. Green, +13

Journal of Chemical Information and Modeling

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

Michael G. Sugiyama, Haotian Cui, Dar’ya S. Redka, +20

Scientific Reports

Drug TargetEngineeringImmunologyMolecular BiologyHost Cell Proteins +22