Paul D. W. Eckford - Concepedia

Author

Paul D. W. Eckford

Also Known As

P. Eckford, P.D.W. Eckford, Paul D W Eckford, Paul D. W. Eckford, Paul D.W. Eckford, Paul DW Eckford, Paul Eckford, Paul D.W. Eckford, Paul D. W. Eckford

Publications

2.4K

Citations

H-Index

Concepts

All Affiliations

Hospital for Sick Children University of Toronto University of Guelph SickKids Foundation

About

Paul D. W. Eckford is an author at Hospital for Sick Children specializing in medicine, natural sciences, and molecular biology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	8	8	524
2	Natural Sciences	7	7	539
3	Biochemistry	5	5	328
4	Engineering	1	1	37
5	Biomedical Engineering	1	1	37

Paul D. W. Eckford

Publications

1.6K

Citations

H-Index

Page 1

	Year	Citations
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner Paul D. W. Eckford, Canhui Li, Mohabir Ramjeesingh, Journal of Biological Chemistry	2012	304
Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator Onofrio Laselva, Claire Bartlett, T. Gunawardena, European Respiratory Journal GeneticsMolecular BiologyPathologyMolecular GeneticsCellular Physiology	2020	162
The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids Paul D. W. Eckford, Frances J. Sharom Biochemical Journal	2005	155
Interaction of the P-Glycoprotein Multidrug Efflux Pump with Cholesterol: Effects on ATPase Activity, Drug Binding and Transport Paul D. W. Eckford, Frances J. Sharom Biochemistry	2008	113
VX-809 and Related Corrector Compounds Exhibit Secondary Activity Stabilizing Active F508del-CFTR after Its Partial Rescue to the Cell Surface Paul D. W. Eckford, Mohabir Ramjeesingh, Steven V. Molinski, Chemistry & Biology	2014	105
<scp>O</scp> rkambi® and amplifier co‐therapy improves function from a rare <i> <scp>CFTR</scp> </i> mutation in gene‐edited cells and patient tissue Steven V. Molinski, Saumel Ahmadi, Wan Ip, EMBO Molecular Medicine	2017	105
Functional Characterization of Escherichia coli MsbA Paul D. W. Eckford, Frances J. Sharom Journal of Biological Chemistry Proteinlipid InteractionBiochemistryNatural SciencesBacteriologyMolecular Biology	2008	103
Structural basis for alginate secretion across the bacterial outer membrane John C. Whitney, Iain D. Hay, Canhui Li, Proceedings of the National Academy of Sciences Protein SecretionAlginate PolymerBiochemistryProtein AssemblyOuter Membrane	2011	95
Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action Onofrio Laselva, Paul D. W. Eckford, Claire Bartlett, Journal of Cystic Fibrosis	2019	68
The reconstituted <i>Escherichia coli</i> MsbA protein displays lipid flippase activity Paul D. W. Eckford, Frances J. Sharom Biochemical Journal Purified MsbaProteinlipid InteractionBiochemistryNatural SciencesVirulence Factor	2010	64

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