Concepedia

Paul D. W. Eckford

PD

19

Publications

1.6K

Citations

16

H-Index

2005

Active since

Affiliations

Hospital for Sick Children(Current)

University of Toronto

University of Guelph

SickKids Foundation

Paul D. W. Eckford is an author at Hospital for Sick Children specializing in medicine, natural sciences, and molecular biology.

Top concepts

Publications per year

2005–2023

19

Publications

19

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner

Paul D. W. Eckford, Canhui Li, Mohabir Ramjeesingh et al. · Journal of Biological Chemistry · 2012 · 304 citations · Full text

Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator

Onofrio Laselva, Claire Bartlett, T. Gunawardena et al. · European Respiratory Journal · 2020 · 162 citations · Full text

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The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

Paul D. W. Eckford, Frances J. Sharom · Biochemical Journal · 2005 · 155 citations · Full text

Interaction of the P-Glycoprotein Multidrug Efflux Pump with Cholesterol: Effects on ATPase Activity, Drug Binding and Transport

Paul D. W. Eckford, Frances J. Sharom · Biochemistry · 2008 · 113 citations

VX-809 and Related Corrector Compounds Exhibit Secondary Activity Stabilizing Active F508del-CFTR after Its Partial Rescue to the Cell Surface

Paul D. W. Eckford, Mohabir Ramjeesingh, Steven V. Molinski et al. · Chemistry & Biology · 2014 · 105 citations

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