Paul D. W. Eckford

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner

Paul D. W. Eckford, Canhui Li, Mohabir Ramjeesingh et al. · Journal of Biological Chemistry · 2012 · 308 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator

Onofrio Laselva, Claire Bartlett, T. Gunawardena et al. · European Respiratory Journal · 2020 · 164 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15

The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

Paul D. W. Eckford, Frances J. Sharom · Biochemical Journal · 2005 · 156 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Interaction of the P-Glycoprotein Multidrug Efflux Pump with Cholesterol: Effects on ATPase Activity, Drug Binding and Transport

Paul D. W. Eckford, Frances J. Sharom · Biochemistry · 2008 · 113 citations

Life Sciences, Biochemistry, Pharmacology +17

VX-809 and Related Corrector Compounds Exhibit Secondary Activity Stabilizing Active F508del-CFTR after Its Partial Rescue to the Cell Surface

Paul D. W. Eckford, Mohabir Ramjeesingh, Steven V. Molinski et al. · Chemistry & Biology · 2014 · 107 citations

Life Sciences, Cell Biology, Molecular Biology +14