David N. Frick

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

Eloise Mastrangelo, Margherita Pezzullo, Tine De Burghgraeve et al. · Journal of Antimicrobial Chemotherapy · 2012 · 426 citations · Full text

Life Sciences, Infectious Diseases, Medicinal Chemistry +17

Studies on the ADP-ribose Pyrophosphatase Subfamily of the Nudix Hydrolases and Tentative Identification of trgB, a Gene Associated with Tellurite Resistance

Christopher Dunn, Suzanne O’Handley, David N. Frick et al. · Journal of Biological Chemistry · 1999 · 149 citations · Full text

Life Sciences, Microbiology, Molecular Biology +9

PSI-7851, a Pronucleotide of β- <scp>d</scp> -2′-Deoxy-2′-Fluoro-2′- <i>C</i> -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

Angela M. Lam, Eisuke Murakami, Christine Espiritu et al. · Antimicrobial Agents and Chemotherapy · 2010 · 140 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Hepatitis C Virus Subgenomic Replicon Requires an Active NS3 RNA Helicase

Angela M. Lam, David N. Frick · Journal of Virology · 2005 · 123 citations · Full text

Life Sciences, Microbiology, Molecular Biology +15

Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3

David N. Frick, Rajdeep S. Virdi, Nemanja Vuksanovic et al. · Biochemistry · 2020 · 121 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17