William Laine

Molecular Determinants of Topoisomerase I Poisoning by Lamellarins:  Comparison with Camptothecin and Structure−Activity Relationships

Esther Marco, William Laine, Christelle Tardy et al. · Journal of Medicinal Chemistry · 2005 · 213 citations

Engineering, Molecular Biology, Lamellarin D +19

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues

Christelle Tardy, Michaël Facompré, William Laine et al. · Bioorganic & Medicinal Chemistry · 2004 · 104 citations

Medicinal Chemistry, Antitumor Agents, Natural Sciences +10

DNA and Non-DNA Targets in the Mechanism of Action of the Antitumor Drug Trabectedin

Marie‐Hélène David‐Cordonnier, Consuelo Gajate, Osvaldo Olmea et al. · Chemistry & Biology · 2005 · 75 citations · Full text

Non-dna Targets, Drug Target, Health Sciences +11

TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence

Valério Farfariello, Dmitri Gordienko, Lina Mesilmany et al. · Nature Communications · 2022 · 74 citations · Full text

DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine.

Christian Bailly, William Laine, Brigitte Baldeyrou et al. · PubMed · 2000 · 60 citations

Molecular Pharmacology, Biochemistry, Antiparasitic Agent +13