William Laine

Molecular Determinants of Topoisomerase I Poisoning by Lamellarins:  Comparison with Camptothecin and Structure−Activity Relationships

Esther Marco, William Laine, Christelle Tardy et al. · Journal of Medicinal Chemistry · 2005 · 213 citations

Natural Sciences, Biochemistry, Chemistry +17

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues

Christelle Tardy, Michaël Facompré, William Laine et al. · Bioorganic & Medicinal Chemistry · 2004 · 104 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence

Valério Farfariello, Dmitri Gordienko, Lina Mesilmany et al. · Nature Communications · 2022 · 82 citations · Full text

Life Sciences, Cell Biology, Oncology +15

DNA and Non-DNA Targets in the Mechanism of Action of the Antitumor Drug Trabectedin

Marie‐Hélène David‐Cordonnier, Consuelo Gajate, Osvaldo Olmea et al. · Chemistry & Biology · 2005 · 77 citations · Full text

Medicine, Oncology, Pharmacology +13

DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine.

Christian Bailly, William Laine, Brigitte Baldeyrou et al. · PubMed · 2000 · 60 citations

Medicine, Medicinal Chemistry, Pharmacology +13