SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, +17

Nature

Signaling PathwayCell RegulationApoptosisImmunologyCellular Apoptosis +4

EGFR activation limits the response of liver cancer to lenvatinib

Haojie Jin, Yuanyuan Lv, Shengxian Yuan, +27

Nature

HepatologyEgfr ActivationHepatocellular CarcinomaMedicineLiver Physiology +8

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

Matthew B. Greenblatt, Jae‐Hyuck Shim, Weiguo Zou, +14

Journal of Clinical Investigation

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Pengda Liu, Michael J. Begley, Wojciech Michowski, +22

Nature

Signal TransductionCell RegulationBiochemistryCarboxyl TerminusNatural Sciences +11

Chimeric Antigen Receptor-Glypican-3 T-Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase I Trials

Donghua Shi, Ahmed O. Kaseb, Xingxing Qi, +11

Clinical Cancer Research

Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

Bo Zhai, Fengli Hu, Xian Jiang, +10

Molecular Cancer Therapeutics

ImmunologyCell DeathCancer BiologyTumor BiologyCell Autophagy +14

Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats

Hui‐Lu Zhang, Le‐Xing Yu, Wen Yang, +18

Journal of Hepatology

InflammationChemically-induced Pro-tumorigenic InflammationProfound ImpactMucosal ImmunologyLiver Physiology +8

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, +18

Nature Cell Biology

Acetylation-Dependent Regulation of Skp2 Function

Hiroyuki Inuzuka, Daming Gao, Lydia W.S. Finley, +15

Cell

Transcriptional RegulationSignal TransductionMolecular RegulationCellular Regulatory MechanismFunctional Regulation +5

MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway

Changjun He, Xuesong Dong, Bo Zhai, +6

Oncotarget