Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

Vincent Hernandez, Thibaut Crépin, Andrés Palencia, +32

Antimicrobial Agents and Chemotherapy

Available AntibioticsMicrobial PathogensLead AnalogueBoron-based AntibacterialsAntimicrobial Chemotherapy +22

Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

Yvonne R. Freund, Tsutomu Akama, M.R. Alley, +12

FEBS Letters

Pharmaceutical SciencePhosphodiesterase 4PharmacotherapyChemical BiologyBoron-based Molecules +19

Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases

Stephen J. Baker, Tsutomu Akama, Yong-Kang Zhang, +9

Bioorganic & Medicinal Chemistry Letters

InflammationMedicinal ChemistryAnti-inflammatoryMedicineImmunology +10

Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents

Tuan P. Tran, Edmund L. Ellsworth, Michael A. Stier, +6

Bioorganic & Medicinal Chemistry Letters

Antimicrobial Drug DiscoveryMedicineAntibacterial AgentStructural–activity RelationshipsAntimicrobial Compound +1

First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms

Tomas Borgegård, Anders Juréus, Fredrik Olsson, +18

Journal of Biological Chemistry

3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors

Nian Zhou, Deqi Guo, George Thomas, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryCysteine Proteases InhibitorsBiochemistryMedicineNatural Sciences +6

3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms

Edmund L. Ellsworth, Tuan P. Tran, Hollis D. Showalter, +15

Journal of Medicinal Chemistry

Bioorganic ChemistryAntiparasitic AgentAntibiotic AdjuvantNew SeriesAntimicrobial Chemotherapy +17

Structure–activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors

Tuan P. Tran, Edmund L. Ellsworth, Joseph P. Sanchez, +15

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyAntimicrobial Drug DiscoveryBiochemistryMedicineNatural Sciences +10

Structure–activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent

Tsutomu Akama, Charlotte Virtucio, Dong Chen, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAnti-inflammatoryDerivativesBiochemistryNatural Sciences +7

A facile synthesis of substituted 3-amino-1<i>H</i>-quinazoline-2,4-diones

Tuan P. Tran, Edmund L. Ellsworth, Brian M. Watson, +8

Journal of Heterocyclic Chemistry