Concepedia

Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents

Tuan P. Tran, Edmund L. Ellsworth, Michael A. Stier, John M. Domagala, Hollis D. Showalter, Stephen J. Gracheck, Martin A. Shapiro, Themis E. Joannides, Rajeshwar Singh

Bioorganic & Medicinal Chemistry Letters · 2004 · 75 citations · 19 references

DOI

Concepts

References

19

DNA gyrase, topoisomerase IV, and the 4-quinolones.

Karl Drlica, Xilin Zhao · Microbiology and Molecular Biology Reviews · 1997 · 891 citations

, , +11

Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

Hiroshi Koga, Akira Itoh, Satoshi Murayama et al. · Journal of Medicinal Chemistry · 1980 · 483 citations

, , +13

Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus

Glenn W. Kaatz, S M Seo, C. A. Ruble · Antimicrobial Agents and Chemotherapy · 1993 · 412 citations

, , +17

New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay

John M. Domagala, Lori Doyle Hanna, Carl L. Heifetz et al. · Journal of Medicinal Chemistry · 1986 · 265 citations

, , +9

Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts

Peter Hüssy, Burkhard Tümmler, U. Schomburg · Antimicrobial Agents and Chemotherapy · 1986 · 186 citations · Full text

, , +16