Carl L. Heifetz

New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay

John M. Domagala, Lori Doyle Hanna, Carl L. Heifetz et al. · Journal of Medicinal Chemistry · 1986 · 265 citations

Life Sciences, Biochemistry, Medicinal Chemistry +9

Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids

Joseph P. Sanchez, John M. Domagala, Susan E. Hagen et al. · Journal of Medicinal Chemistry · 1988 · 136 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11

1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure activity relationships at N1 for the quinolone antibacterials

John M. Domagala, Carl L. Heifetz, Marland P. Hutt et al. · Journal of Medicinal Chemistry · 1988 · 96 citations

Pharmacy, Chemistry, Medicinal Chemistry +11

Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity

Joseph P. Sanchez, Carl L. Heifetz, Steven R. Priebe et al. · Journal of Medicinal Chemistry · 1992 · 40 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids

Susan E. Hagen, Carl L. Heifetz · Journal of Medicinal Chemistry · 1991 · 37 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13