New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay

John M. Domagala, Lori Doyle Hanna, Carl L. Heifetz, +4

Journal of Medicinal Chemistry

Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids

Joseph P. Sanchez, John M. Domagala, Susan E. Hagen, +4

Journal of Medicinal Chemistry

Antibacterial AgentsBioorganic ChemistryAntibacterial ActivityBenzoxazine 10-PositionAntimicrobial Chemotherapy +17

1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure activity relationships at N1 for the quinolone antibacterials

John M. Domagala, Carl L. Heifetz, Marland P. Hutt, +4

Journal of Medicinal Chemistry

2‐Phenyl‐5‐(trichloromethyl)‐1,3,4‐oxadiazoles, A new class of antimalarial substances

Marland P. Hutt, Edward F. Elslager, Leslie M. Werbel

Journal of Heterocyclic Chemistry

Trichloromethyl 1,2,4‐OxadiazoleAntifungal AgentDiversity Oriented SynthesisAntiparasitic AgentMedicine +11

7-Substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials

John M. Domagala, Susan E. Hagen, Carl L. Heifetz, +4

Journal of Medicinal Chemistry

Bioorganic ChemistryAltmetric Attention ScoreOrganic ChemistryAntimicrobial ChemotherapyHeterocycle Chemistry +14

Antimalarial activity of 2-(substituted amino)-4,6-bis(trichloromethyl)-1,3,5-triazines and N-(chlorophenyl)-N'-[4-(substituted amino)-6-(trichloromethyl)-1,3,5-triazin-2-yl]guanidines

Leslie M. Werbel, Edward F. Elslager, Carolyn Hess, +1

Journal of Medicinal Chemistry

\documentclass{article}\pagestyle{empty}\begin{document}$ \left[\!\left[ {} \right.\right. $ \end{document}[(Dialkylamino)alkyl]amino\documentclass{article}\pagestyle{empty}\begin{document}$ \left.\left. {} \right]\!\right] $ \end{document}pyrimido[1,2‐<i>a</i>]benzimidazoles,2,3‐dihydro‐1<i>H</i>‐cyclopenta[4,5]pyrimido[1,2‐<i>a</i>]benzimidazoles, and <i>s</i>‐triazolo[1,5‐<i>a</i>]pyrimidines as potential antimalarial agents

Leslie M. Werbel, Ann Curry, Edward F. Elslager, +3

Journal of Heterocyclic Chemistry

Molecular PharmacologyMedicinal ChemistryNmr SpectroscopyAntiparasitic AgentNatural Sciences +13

Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides

Edward F. Elslager, Norman L. Colbry, John Davoll, +3

Journal of Medicinal Chemistry

Bioorganic ChemistryAntiparasitic AgentAntimicrobial ChemotherapyHeterocycle ChemistryPharmaceutical Chemistry +14

Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone)

G. W. Moersch, Mildred C. Rebstock, Eugene L. Wittle, +6

Journal of Medicinal Chemistry

Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine

John S. Kiely, Marland P. Hutt, Townley P. Culbertson, +7

Journal of Medicinal Chemistry