Gary L. Schieven

Discovery of <i>N</i>-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Louis J. Lombardo, Francis Y. Lee, Ping Chen et al. · Journal of Medicinal Chemistry · 2004 · 1.3K citations · Full text

Medicine, Oncology, Pharmacology +13

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

C H June, Mary C. Fletcher, J A Ledbetter et al. · Proceedings of the National Academy of Sciences · 1990 · 502 citations

Life Sciences, Biochemistry, Immunology +17

2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of <i>N</i> -(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent <i>pan</i> -Src Kinase Inhibitor

Jagabandhu Das, Ping Chen, Derek Norris et al. · Journal of Medicinal Chemistry · 2006 · 400 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation

Andrew E. Schade, Gary L. Schieven, Robert Townsend et al. · Blood · 2007 · 300 citations · Full text

Life Sciences, Oncology, Pharmacology +14

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

Peter A. Kiener, Bruce Rankin, Anne L. Burkhardt et al. · Journal of Biological Chemistry · 1993 · 196 citations · Full text

Life Sciences, Cell Biology, Immunology +17