Denis T. Akan

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Timothy R. Hodges, Jason R. Abbott, Andrew J. Little et al. · Journal of Medicinal Chemistry · 2018 · 52 citations · Full text

Combinatorial Chemistry, Gtp-bound Ras, Molecular Biology +27

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling

Jason R. Abbott, Timothy R. Hodges, R. Nathan Daniels et al. · Journal of Medicinal Chemistry · 2018 · 41 citations · Full text

Small Molecule–Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1

Jennifer E. Howes, Denis T. Akan, Michael C. Burns et al. · Molecular Cancer Therapeutics · 2018 · 39 citations

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS

Jason R. Abbott, Pratiq A. Patel, Jennifer E. Howes et al. · ACS Medicinal Chemistry Letters · 2018 · 28 citations · Full text

Molecular Biology, Chemical Biology, Ras Signaling +18

Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling <i>via</i> Independent Cellular Responses

Denis T. Akan, Jennifer E. Howes, Jiqing Sai et al. · ACS Chemical Biology · 2019 · 18 citations

Pi3k Signaling, Molecular Regulation, Molecular Biology +16