Richard A. Brier

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans

Patrick C. May, Brian A. Willis, Stephen L. Lowe et al. · Journal of Neuroscience · 2015 · 195 citations · Full text

Amyloid β, Neurodegenerative Diseases, Amyloid Lowering +15

Substituted 3-Imidazo[1,2-<i>a</i>]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-<i>hi</i>]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3

Thomas A. Engler, James R. Henry, Sushant Malhotra et al. · Journal of Medicinal Chemistry · 2004 · 100 citations · Full text

Insulin Receptor, Pharmaceutical Chemistry, Insulin Signaling +18

Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm

Prabhakar K. Jadhav, Matthew A. Schiffler, Kostas Gavardinas et al. · ACS Medicinal Chemistry Letters · 2014 · 65 citations · Full text

Molecular Docking, Medicinal Chemistry, Pharmaceutical Chemistry +15

The development of potent and selective bisarylmaleimide GSK3 inhibitors

Thomas A. Engler, Sushant Malhotra, Timothy P. Burkholder et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 60 citations · Full text

Medicinal Chemistry, Medicine, Pharmacotherapy +5

Relationship between rat renal accumulation of gentamicin, tobramycin, and netilmicin and their nephrotoxicities

Michael E. Brier, Petra Mayer, Richard A. Brier et al. · Antimicrobial Agents and Chemotherapy · 1985 · 28 citations

Renal Pathology, Renal Inflammation, Renal Accumulation Kinetics +16