Keiji Kosugi

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery

Keiichi Kuwano, Asami Hashino, Kumiko Noda et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 87 citations

Endothelium removal augments endothelium‐independent vasodilatation in rat mesenteric vascular bed

Yukiko Iwatani, Keiji Kosugi, S Isobe‐Oku et al. · British Journal of Pharmacology · 2008 · 27 citations · Full text

Antiproliferative and apoptotic effects of norethisterone on endometriotic stromal cells in vitro

Toshiyuki Minami, Keiji Kosugi, Izumi Suganuma et al. · European Journal of Obstetrics & Gynecology and Reproductive Biology · 2012 · 25 citations

Infertility, Hormonal Contraceptive, Fertility +10

A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonary arteries

Chiaki Fuchikami, Kohji Murakami, Koyuki Tajima et al. · European Journal of Pharmacology · 2016 · 18 citations

Medicinal Chemistry, Vasodilation Mode, Medicine +10

The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats

Yohei Honda, Keiji Kosugi, Chiaki Fuchikami et al. · PLoS ONE · 2020 · 11 citations · Full text

Hypertension, Heart Failure, Pulmonary Arterial Hypertension +15