Leroy C. Joseph

Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function

Leroy C. Joseph, Dimitra Kokkinaki, Mesele-Christina Valenti et al. · JCI Insight · 2017 · 154 citations · Full text

Heart Failure, Mitochondrial Dysfunction, Cardiovascular Toxicity +17

ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene

Maria Chatzifrangkeskou, Caroline Le Dour, Wei Wu et al. · Human Molecular Genetics · 2016 · 103 citations · Full text

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

Leroy C. Joseph, Emanuele Barca, Prakash Subramanyam et al. · PLoS ONE · 2016 · 98 citations · Full text

Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia

Leroy C. Joseph, Prakash Subramanyam, Christopher Radlicz et al. · Heart Rhythm · 2016 · 50 citations

Mitochondrial Oxidative Stress, Cardiomyopathy, Heart Failure +11

ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy

Susumu Antoku, Wei Wu, Leroy C. Joseph et al. · Developmental Cell · 2019 · 44 citations · Full text

Cardiac Laminopathy, Cardiac Muscle, Fhod Connects Signaling +13