Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy

Sheetal Gandotra, Caroline Le Dour, William Bottomley, +15

New England Journal of Medicine

ObesityMetabolic SyndromeLipid SynthesisBiochemistryMetabolic Disorder +13

ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene

Maria Chatzifrangkeskou, Caroline Le Dour, Wei Wu, +11

Human Molecular Genetics

LMNA Mutations Induce a Non-Inflammatory Fibrosis and a Brown Fat-Like Dystrophy of Enlarged Cervical Adipose Tissue

Véronique Béréziat, Pascale Cervera, Caroline Le Dour, +5

American Journal Of Pathology

Decreased WNT/β-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene

Caroline Le Dour, Coline Macquart, Fusako Sera, +5

Human Molecular Genetics

Cardiac MuscleHeart FailureGeneticsCardiac Progenitor CellsCardiac Regeneration +20

Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations

Caroline Le Dour, Maria Chatzifrangkeskou, Coline Macquart, +16

Nature Communications

Microtubule cytoskeleton regulates Connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene

Coline Macquart, René Jüttner, Blanca Morales Rodríguez, +7

Human Molecular Genetics

Cardiac MuscleEngineeringCardiac RegenerationCytoskeletonMechanotransduction +20

A Homozygous Mutation of Prelamin-A Preventing Its Farnesylation and Maturation Leads to a Severe Lipodystrophic Phenotype: New Insights into the Pathogenicity of Nonfarnesylated Prelamin-A

Caroline Le Dour, Stéphane Schneebeli, Fawzi Bakiri, +10

The Journal of Clinical Endocrinology & Metabolism

Extracellular matrix remodeling and transforming growth factor-β signaling abnormalities induced by lamin A/C variants that cause lipodystrophy

Caroline Le Dour, Wei Wu, Véronique Béréziat, +3

Journal of Lipid Research

The R439C mutation in <i>LMNA</i> causes lamin oligomerization and susceptibility to oxidative stress

Valerie L. R. M. Verstraeten, Sandrine M. Caputo, Maurice A. M. Van Steensel, +14

Journal of Cellular and Molecular Medicine

R439c MutationGeneticsMolecular BiologyMolecular GeneticsDisease Gene Identification +15

Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice

Ji‐Yeon Shin, Caroline Le Dour, Fusako Sera, +6

Nucleus

Cardiac MuscleHeart FailureCardiovascular FunctionInflammationLamina-associated Polypeptide 1 +15