Temsirolimus Activates Autophagy and Ameliorates Cardiomyopathy Caused by Lamin A/C Gene Mutation

Jason C. Choi, Antoine Muchir, Wei Wu, +4

Science Translational Medicine

Cell AutophagyMitophagyHeart FailureCardiomyopathyAutoimmune Disease +12

MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-β signaling

Feng Lin, Juliet Morrison, Wei Wu, +1

Human Molecular Genetics

Reporter GeneCellular PhysiologySignaling PathwayCell RegulationBone Morphogenic Protein +14

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

Wei Wu, Antoine Muchir, Jian Shan, +2

Circulation

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

Fanjun Meng, Dongdong Yao, Yang Shi, +8

Molecular Neurodegeneration

ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene

Maria Chatzifrangkeskou, Caroline Le Dour, Wei Wu, +11

Human Molecular Genetics

Intracellular trafficking of MAN1, an integral protein of the nuclear envelope inner membrane

Wei Wu, Feng Lin, Howard J. Worman

Journal of Cell Science

Membrane FusionChromatinInner Nuclear MembraneProtein FunctionSignal Transduction +12

Reduced expression of A-type lamins and emerin activates extracellular signal-regulated kinase in cultured cells

Antoine Muchir, Wei Wu, Howard J. Worman

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Cultured CellsCell PhysiologyDevelopmental BiologySignal TransductionCell Regulation +9

Dual Specificity Phosphatase 4 Mediates Cardiomyopathy Caused by Lamin A/C (LMNA) Gene Mutation

Jason C. Choi, Wei Wu, Antoine Muchir, +3

Journal of Biological Chemistry

Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene

Wei Wu, Jian Shan, Gisèle Bonne, +2

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Cardiac MuscleCardiomyopathyHeart FailureCardiac ReprogrammingPhysiology +8

Inhibition of TGF-β Signaling at the Nuclear Envelope: Characterization of Interactions Between MAN1, Smad2 and Smad3, and PPM1A

Benjamin Bourgeois, Bernard Gilquin, Carine Tellier-Lebègue, +7

Science Signaling

Transcriptional RegulationTissue DevelopmentGene Lemd3Bone Morphogenic ProteinSignaling Pathway +16