Ian Churcher

Catalytic in vivo protein knockdown by small-molecule PROTACs

Daniel P. Bondeson, Alina Mares, Ian E. Smith et al. · Nature Chemical Biology · 2015 · 1.3K citations · Full text

Biochemistry, Protein Assembly, Natural Sciences +2

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Alina Mares, Afjal H. Miah, Ian E. Smith et al. · Communications Biology · 2020 · 209 citations · Full text

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

Dirk Beher, Earl E. Clarke, Jonathan D.J. Wrigley et al. · Journal of Biological Chemistry · 2004 · 178 citations · Full text

Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach

Zuni I. Bassi, Martin C. Fillmore, Afjal H. Miah et al. · ACS Chemical Biology · 2018 · 173 citations

Inflammation, P300/cbp-associated Factor, Molecular Immunology +15

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool

Ignacio Colomer, Christopher J. Empson, Philip G. E. Craven et al. · Chemical Communications · 2016 · 87 citations · Full text

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +22