Concepedia

Author

Ian Churcher

GlaxoSmithKline (United Kingdom)ORCID

Also Known As

Churcher, Ian, I Churcher, I. CHURCHER, I. Churcher, Ian Churcher

75

Publications

5.7K

Citations

29

H-Index

64

Concepts

All Affiliations

GlaxoSmithKline (United Kingdom)Age UKUniversity of NottinghamMerck & Co., Inc., Rahway, NJ, USA (United States)MSD (UK) Limited (United Kingdom)
IC

About

Ian Churcher is an author at GlaxoSmithKline (United Kingdom) specializing in natural sciences, pharmacology, and biochemistry.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Natural Sciences

15

18

1.9K

2

Biochemistry

13

14

1.8K

3

Medicine

10

10

546

4

Engineering

8

8

292

5

Biomolecular Engineering

5

5

208

Ian Churcher

×

32

Publications

3.1K

Citations

25

H-Index

YearCitations

Catalytic in vivo protein knockdown by small-molecule PROTACs

Daniel P. Bondeson, Alina Mares, Ian E. Smith,

Nature Chemical Biology

2015

1.3K

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Alina Mares, Afjal H. Miah, Ian E. Smith,

Communications Biology

2020

209

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

Dirk Beher, Earl E. Clarke, Jonathan D.J. Wrigley,

Journal of Biological Chemistry

2004

178

Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach

Zuni I. Bassi, Martin C. Fillmore, Afjal H. Miah,

ACS Chemical Biology

2018

173

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool

Ignacio Colomer, Christopher J. Empson, Philip G. E. Craven,

Chemical Communications

2016

87

Structural Insights into PROTAC-Mediated Degradation of Bcl-xL

Chun‐wa Chung, Han Dai, Esther Fernández,

ACS Chemical Biology

2020

86

The Novel γ Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse

Jonathan D. Best, David W. Smith, Michael Reilly,

Journal of Pharmacology and Experimental Therapeutics

2006

83

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Ian Churcher, Dirk Beher, Jonathan D. Best,

Bioorganic & Medicinal Chemistry Letters

2005

78

A unified lead-oriented synthesis of over fifty molecular scaffolds

Richard G. Doveston, Paolo Tosatti, Mark Dow,

Organic & Biomolecular Chemistry

2014

72

Optimization of a Series of RIPK2 PROTACs

Afjal H. Miah, Ian E. Smith, M.D. Rackham,

Journal of Medicinal Chemistry

2021

65

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