H.D. Sarath Liyanage

Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors

Kevin O. Hicks, Bronwyn G. Siim, Jagdish K. Jaiswal et al. · Clinical Cancer Research · 2010 · 129 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

DNA-Targeted 1,2,4-Benzotriazine 1,4-Dioxides:  Potent Analogues of the Hypoxia-Selective Cytotoxin Tirapazamine

Michael P. Hay, Frederik B. Pruijn, Swarna A. Gamage et al. · Journal of Medicinal Chemistry · 2003 · 66 citations

Medicine, Oncology, Pharmacology +13

Extravascular Transport of Drugs in Tumor Tissue:  Effect of Lipophilicity on Diffusion of Tirapazamine Analogues in Multicellular Layer Cultures

Frederik B. Pruijn, Joanna R. Sturman, H.D. Sarath Liyanage et al. · Journal of Medicinal Chemistry · 2005 · 56 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy

Moana Tercel, Ho H. Lee, Sunali Mehta et al. · Journal of Medicinal Chemistry · 2017 · 36 citations

Medicine, Oncology, Pharmacology +15

Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine <i>N</i> 3 DNA minor groove alkylators

William R. Wilson, Stephen M. Stribbling, Frederik B. Pruijn et al. · Molecular Cancer Therapeutics · 2009 · 34 citations

Medicine, Medicinal Chemistry, Pharmacology +15