Frederik B. Pruijn

Use of Three-Dimensional Tissue Cultures to Model Extravascular Transport and Predict In Vivo Activity of Hypoxia-Targeted Anticancer Drugs

Kevin O. Hicks, Frederik B. Pruijn, Timothy W. Secomb et al. · JNCI Journal of the National Cancer Institute · 2006 · 150 citations

Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors

Kevin O. Hicks, Bronwyn G. Siim, Jagdish K. Jaiswal et al. · Clinical Cancer Research · 2010 · 127 citations

Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine

Michael P. Hay, Swarna A. Gamage, Mary S. Kovacs et al. · Journal of Medicinal Chemistry · 2002 · 111 citations

Pharmaceutical Science, Hypoxia-selective Analogues, Pharmacotherapy +16

Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures.

Kevin O. Hicks, Frederik B. Pruijn, Joanna R. Sturman et al. · PubMed · 2003 · 108 citations

Cellular Pharmacology, Pharmacotherapy, Cellular Physiology +23

Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

Bronwyn G. Siim, Alan Lee, Sahar Shalal-Zwain et al. · Cancer Chemotherapy and Pharmacology · 2003 · 95 citations

Pharmaceutical Science, Pharmacology, Marked Potentiation +7