Bronwyn G. Siim

Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors

Kevin O. Hicks, Bronwyn G. Siim, Jagdish K. Jaiswal et al. · Clinical Cancer Research · 2010 · 129 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model

Kevin O. Hicks, Yvette Fleming, Bronwyn G. Siim et al. · International Journal of Radiation Oncology*Biology*Physics · 1998 · 100 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

Hypoxia-specific cytotoxins in cancer therapy

J. Martin Brown, Bronwyn G. Siim · Seminars in Radiation Oncology · 1996 · 97 citations · Full text

Medicine, Oncology, Radiation Oncology +16

Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

Bronwyn G. Siim, Alan Lee, Sahar Shalal-Zwain et al. · Cancer Chemotherapy and Pharmacology · 2003 · 95 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Oxygen Dependence and Extravascular Transport of Hypoxia-Activated Prodrugs: Comparison of the Dinitrobenzamide Mustard PR-104A and Tirapazamine

Kevin O. Hicks, Hilary Myint, Adam V. Patterson et al. · International Journal of Radiation Oncology*Biology*Physics · 2007 · 71 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12