Amir Ashoorzadeh

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy

Janine N. Copp, Alexandra M. Mowday, Elsie M. Williams et al. · Cell chemical biology · 2017 · 79 citations · Full text

Pet Probes, Multifunctional Nitroreductase, Biochemistry +11

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A

Gareth A. Prosser, Janine N. Copp, Alexandra M. Mowday et al. · Biochemical Pharmacology · 2013 · 73 citations

Engineering, Biochemistry, Reactive Nitrogen Specie +8

Selective Treatment of Hypoxic Tumor Cells In Vivo: Phosphate Pre‐Prodrugs of Nitro Analogues of the Duocarmycins

Moana Tercel, Graham J. Atwell, Shangjin Yang et al. · Angewandte Chemie International Edition · 2011 · 47 citations

Cellular Pharmacology, Pharmacotherapy, Nitro Analogues +18

Nitro <i>seco</i> Analogues of the Duocarmycins Containing Sulfonate Leaving Groups as Hypoxia-Activated Prodrugs for Cancer Therapy

Ralph J. Stevenson, William A. Denny, Moana Tercel et al. · Journal of Medicinal Chemistry · 2012 · 27 citations

Cancer Therapy, Pharmaceutical Science, Large Hcrs +17

2-Oxo-3, 4-dihydropyrimido[4, 5- d ]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

Xueqiang Li, Christopher P. Guise, Rana Taghipouran et al. · European Journal of Medicinal Chemistry · 2017 · 26 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +7