Alexandra M. Mowday

Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302

Fanying Meng, James Evans, Deepthi Bhupathi et al. · Molecular Cancer Therapeutics · 2011 · 203 citations

Pharmacotherapy, Redox Biology, Oxidative Stress +18

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy

Janine N. Copp, Alexandra M. Mowday, Elsie M. Williams et al. · Cell chemical biology · 2017 · 79 citations · Full text

Pet Probes, Multifunctional Nitroreductase, Biochemistry +11

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A

Gareth A. Prosser, Janine N. Copp, Alexandra M. Mowday et al. · Biochemical Pharmacology · 2013 · 73 citations

Engineering, Biochemistry, Reactive Nitrogen Specie +8

Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954

Pearl M. Swe, Janine N. Copp, L.K. Green et al. · Biochemical Pharmacology · 2012 · 46 citations

Medicinal Chemistry, Biochemistry, Anticancer Prodrug Cb1954 +8

<i>E. coli</i> nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications

Alexandra M. Mowday, Janine N. Copp, Sophie P. Syddall et al. · Theranostics · 2020 · 24 citations · Full text