Shangjin Yang

Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

Adam V. Patterson, Dianne M. Ferry, Shelley J. Edmunds et al. · Clinical Cancer Research · 2007 · 247 citations · Full text

Medicine, Oncology, Pharmacology +16

Effect of Nitroreduction on the Alkylating Reactivity and Cytotoxicity of the 2,4-Dinitrobenzamide-5-aziridine CB 1954 and the Corresponding Nitrogen Mustard SN 23862:  Distinct Mechanisms of Bioreductive Activation

Nuala A. Helsby, S. James Wheeler, Frederik B. Pruijn et al. · Chemical Research in Toxicology · 2003 · 73 citations

Medicine, Medicinal Chemistry, Oncology +12

Selective Treatment of Hypoxic Tumor Cells In Vivo: Phosphate Pre‐Prodrugs of Nitro Analogues of the Duocarmycins

Moana Tercel, Graham J. Atwell, Shangjin Yang et al. · Angewandte Chemie International Edition · 2011 · 48 citations

Medicine, Medicinal Chemistry, Pharmacology +12

Hypoxia-Activated Prodrugs: Substituent Effects on the Properties of Nitro <i>seco</i>-1,2,9,9a-Tetrahydrocyclopropa[<i>c</i>]benz[<i>e</i>]indol-4-one (nitroCBI) Prodrugs of DNA Minor Groove Alkylating Agents

Moana Tercel, Graham J. Atwell, Shangjin Yang et al. · Journal of Medicinal Chemistry · 2009 · 47 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Synthesis and Structure−Activity Relationships for 2,4-Dinitrobenzamide-5-mustards as Prodrugs for the <i>Escherichia coli</i> <i>nfsB</i> Nitroreductase in Gene Therapy

Graham J. Atwell, Shangjin Yang, Frederik B. Pruijn et al. · Journal of Medicinal Chemistry · 2007 · 38 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14