Systemic Administration of C-Type Natriuretic Peptide as a Novel Therapeutic Strategy for Skeletal Dysplasias

Akihiro Yasoda, Hidetomo Kitamura, Toshihito Fujii, +7

Endocrinology

C-type Natriuretic PeptidePeptide SciencePeptide TherapeuticsOsteoporosisOrthopaedic Surgery +14

Simple and sensitive quantification of bioactive peptides in biological matrices using liquid chromatography/selected reaction monitoring mass spectrometry coupled with trichloroacetic acid clean‐up

Naoaki Murao, Masaki Ishigai, Hideyuki Yasuno, +2

Rapid Communications in Mass Spectrometry

Biological Mass SpectrometryPeptide TherapeuticsBioanalysisSynthetic Parathyroid HormoneParathyroid Hormone +17

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

Atsushi Ohta, Mikimasa Tanada, Shojiro Shinohara, +44

Journal of the American Chemical Society

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent

Yoshiaki Isshiki, Yasunori Kohchi, Hitoshi Iikura, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineAvailable Anticancer AgentAnti-cancer AgentDrug Development +4

Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment

Futa Mimoto, K. Tatsumi, Shun Shimizu, +37

Cell Reports

Cancer ImmunosurveillanceElevated Extracellular AtpMedicineImmunologyBiological Microenvironments +13

Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models

Tatsuya Tamura, Yoshinobu Higuchi, Hidetomo Kitamura, +4

Arthritis Research & Therapy

Separation and Detection of Bile Acid 24-Glucuronides in Human Urine by Liquid Chromatography Combined with Electrospray Ionization Mass Spectrometry

Shigeo Ikegawa, Hiroko Okuyama, Junji Oohashi, +2

Analytical Sciences

Human UrineUrologyBiochemistryLiquid Chromatography CombinedBiliary Tract +10

Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats

Takumi Nagata, Masanori Fukazawa, Kiyofumi Honda, +10

American Journal of Physiology-Endocrinology and Metabolism

Glucose TitrationRenal InflammationMetabolic SyndromeMolecular PharmacologyRenal Function +17

Separatory Determination of Bile Acid 3-Sulfates by Liquid Chromatography/Electrospray Ionization Mass Spectrometry

Shigeo Ikegawa, Takamitsu Yanagihara, Naoaki Murao, +2

Journal of Mass Spectrometry

Human UrineEngineeringBiochemistryBiliary TractMedicine +13

Separation and Detection of Bile Acid 3-Glucuronides in Human Urine by Liquid Chromatography/Electrospray Ionization-Mass Spectrometry

Shigeo Ikegawa, Naoaki Murao, T. Motoyama, +2

Biomedical Chromatography