Concepedia

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent

Yoshiaki Isshiki, Yasunori Kohchi, Hitoshi Iikura, Yasuaki Matsubara, Kohsuke Asoh, Takeshi Murata, Masami Kohchi, Eisaku Mizuguchi, Shinji Tsujii, Kazuo Hattori,

Bioorganic & Medicinal Chemistry Letters · 2011 · 77 citations · 15 references

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References

15

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

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ras oncogenes in human cancer: a review.

Joyce Bos · PubMed · 1989 · 5.1K citations

, , +17

The mitogen-activated protein kinase signal transduction pathway

Roger J. Davis · Journal of Biological Chemistry · 1993 · 2.2K citations · Full text

, , +12

BRAF Mutation in Papillary Thyroid Carcinoma

Yoram Cohen, Mingzhao Xing, Elizabeth Mambo et al. · JNCI Journal of the National Cancer Institute · 2003 · 924 citations · Full text

, , +14

High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines.

Xiulong Xu, Roderick M. Quiros, Paolo Gattuso et al. · PubMed · 2003 · 423 citations

, , +17