Roberto Colon-Cruz

New hydroxy-pyrazoline intermediates, subtle regio-selectivity and relative reaction rate variations observed during acid catalyzed and neutral pyrazole cyclization

Timothy Norris, Roberto Colon-Cruz, David H. Brown Ripin · Organic & Biomolecular Chemistry · 2005 · 88 citations

Sulfuric Acid, Engineering, Heterocyclic +14

Developing an Asymmetric Transfer Hydrogenation Process for (<i>S</i>)-5-Fluoro-3-methylisobenzofuran-1(3<i>H</i>)-one, a Key Intermediate to Lorlatinib

Shengquan Duan, Bryan Li, Robert W. Dugger et al. · Organic Process Research & Development · 2017 · 35 citations

Halogenation, Boron Reduction, Asymmetric Transfer Hydrogenation +15

Development of a Second-Generation Process to Antibacterial Candidate Sulopenem

Steven J. Brenek, Stéphane Caron, Esmort Chisowa et al. · Organic Process Research & Development · 2012 · 11 citations

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +18

Synthesis of Filibuvir. Part II. Second-Generation Synthesis of a 6,6-Disubstituted 2<i>H</i>-Pyranone via Dieckmann Cyclization of a β-Acetoxy Ester

Zhihui Peng, John A. Ragan, Roberto Colon-Cruz et al. · Organic Process Research & Development · 2013 · 10 citations

Dieckmann Cyclization, Enantioselective Synthesis, Improved Sequence +13