Commercial Route Research and Development for SGLT2 Inhibitor Candidate Ertugliflozin

Paul Bowles, Steven J. Brenek, Stéphane Caron, +21

Organic Process Research & Development

Combinatorial ChemistryBioorganic ChemistryOrganic ChemistryPharmacotherapyMethylpiperazine Amide +17

A Calorimetric Investigation To Safely Scale-Up a Curtius Rearrangement of Acryloyl Azide

David J. am Ende, Keith M. DeVries, Pamela Clifford, +1

Organic Process Research & Development

DerivativesEngineeringHeterocyclicCalorimetric InvestigationChemical Derivative +9

Safe Execution of a Large-Scale Ozonolysis:  Preparation of the Bisulfite Adduct of 2-Hydroxyindan-2-carboxaldehyde and Its Utility in a Reductive Amination

John A. Ragan, David J. am Ende, Steven J. Brenek, +6

Organic Process Research & Development

EngineeringSafe ExecutionOrganic ChemistryChemistryDesulfurization +14

Preparation of Grignard Reagents:  FTIR and Calorimetric Investigation for Safe Scale-Up

David J. am Ende, Pamela Clifford, David M. DeAntonis, +2

Organic Process Research & Development

Food ChemistrySafe Scale-upChemical EngineeringOrganic HalideEngineering +13

Development and Application of Laboratory Tools To Predict Particle Properties upon Scale-Up in Agitated Filter-Dryers

David J. am Ende, Melissa Birch, Steven J. Brenek, +1

Organic Process Research & Development

Agitated Filter-dryersEngineeringFluid MechanicsMechanical EngineeringParticle Method +24

Determination of flash point in air and pure oxygen using an equilibrium closed bomb apparatus

Dehong Kong, David J. am Ende, Steven J. Brenek, +1

Journal of Hazardous Materials

Flash PointEngineeringDetonation PhenomenonAerospace EngineeringBlast Engineering +2

A safe, scaleable method for the oxidation of carbon–boron bonds with oxone®

David H. Brown Ripin, Weiling Cai, Steven J. Brenek

Tetrahedron Letters

Materials ScienceChemical EngineeringEngineeringOxidation ResistanceOrganic Chemistry +6

The use of borane–amine adducts as versatile palladium-catalyzed hydrogen-transfer reagents in methanol

Michel Couturier, Brian M. Andresen, John L. Tucker, +3

Tetrahedron Letters

Chemical EngineeringEngineeringMethanolOrganic ChemistryBorane–amine Adducts +6

Practical Large-Scale Synthesis of 3,4-Isopropylidenedioxypyrrolidine Hydrotosylate:  Atom Economical Self-Hydrogenolysis of a Crystalline Borane−Benzylamine Adduct

Michel Couturier, Brian M. Andresen, Jeffrey B. Jorgensen, +6

Organic Process Research & Development

Diversity Oriented SynthesisEngineeringBiochemistryPractical Large-scale SynthesisEfficient Four-step Sequence +13

Computational fluid dynamics modeling of mixing effects for crystallization in coaxial nozzles

C. Pirkle, Lucas C. Foguth, Steven J. Brenek, +2

Chemical Engineering and Processing - Process Intensification

EngineeringFluid MechanicsMechanical EngineeringNumerical SimulationApplied Physics +8