Aqueous Phosphoric Acid as a Mild Reagent for Deprotection of <i>tert</i>-Butyl Carbamates, Esters, and Ethers

Bryan Li, Martin A. Berliner, Richard A. Buzon, +15

The Journal of Organic Chemistry

Mild ReagentEngineeringBiochemistryAqueous Phosphoric AcidCyclic Carbamate +10

Telescoped Flow Process for the Syntheses of <i>N</i>-Aryl Pyrazoles

Bryan Li, Daniel W. Widlicka, Steven J. Boucher, +9

Organic Process Research & Development

N-aryl PyrazoleChemical EngineeringEngineeringN-aryl PyrazolesOrganic Chemistry +7

Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections

Thomas V. Magee, Matthew F. Brown, Jeremy T. Starr, +32

Journal of Medicinal Chemistry

Vitro PotencyNovel Polymyxin AnaloguesHealth SciencesAntibioticsAntimicrobial Susceptibility +13

Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

Thomas V. Magee, Sharon L. Ripp, Bryan Li, +35

Journal of Medicinal Chemistry

Health SciencesAntibioticsMedicineKlebsiella PneumoniaeMacrolides Addresses Resistance +12

Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response

Kim F. McClure, Etzer Darout, Cristiano R. W. Guimarães, +19

Journal of Medicinal Chemistry

G-protein-coupled Receptor 119PharmacotherapyHeterocycle ChemistryMolecular PharmacologyMedicinal Chemistry +18

Deprotection of <i>N</i>-Boc Groups under Continuous-Flow High-Temperature Conditions

Bryan Li, Ruizhi Li, Peter H. Dorff, +6

The Journal of Organic Chemistry

Derivative (Chemistry)EngineeringContinuous-flow High-temperature ConditionsApplied PhysicsSuperconductivity +13

An Optimized Process for Formation of 2,4-Disubstituted Imidazoles from Condensation of Amidines and α-Haloketones

Bryan Li, Charles K.‐F. Chiu, Richard F. Hank, +3

Organic Process Research & Development

EngineeringPotassium BicarbonateVigorous Reflux2,4-Disubstituted ImidazolesOptimized Process +7

Aqueous phosphoric acid as a mild reagent for deprotection of the t-butoxycarbonyl group

Bryan Li, Raymond J. Bemish, Richard A. Buzon, +7

Tetrahedron Letters

Bioorganic ChemistryMild ReagentBiochemistryT-butoxycarbonyl GroupNatural Sciences +3

Developing an Asymmetric Transfer Hydrogenation Process for (<i>S</i>)-5-Fluoro-3-methylisobenzofuran-1(3<i>H</i>)-one, a Key Intermediate to Lorlatinib

Shengquan Duan, Bryan Li, Robert W. Dugger, +7

Organic Process Research & Development

HalogenationBoron ReductionAsymmetric Transfer HydrogenationKey IntermediateEngineering +13

Continuous Production of Anhydrous <i>tert</i>-Butyl Hydroperoxide in Nonane Using Membrane Pervaporation and Its Application in Flow Oxidation of a γ-Butyrolactam

Bryan Li, Steven M. Guinness, Steve Hoagland, +19

Organic Process Research & Development

Advanced Oxidation ProcessMedicinal ChemistryChemical EngineeringEngineeringPharmaceutical Chemistry +13