Cristiano R. W. Guimarães

Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction

Xiaoqi Chen, David J. Kopecky, Jeff Mihalic et al. · Journal of Medicinal Chemistry · 2012 · 218 citations · Full text

Molecular Biology, Chemical Biology, Protein Synthesis +17

MM-GB/SA Rescoring of Docking Poses in Structure-Based Lead Optimization

Cristiano R. W. Guimarães, Mario Cardozo · Journal of Chemical Information and Modeling · 2008 · 214 citations

Engineering, Computer-aided Design, Computational Chemistry +20

Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics

Dale L. Boger, Hiroshi Miyauchi, Wu Du et al. · Journal of Medicinal Chemistry · 2004 · 213 citations · Full text

Pharmaceutical Science, Drug Target, Pain Medicine +21

Elucidation of Fatty Acid Amide Hydrolase Inhibition by Potent α-Ketoheterocycle Derivatives from Monte Carlo Simulations

Cristiano R. W. Guimarães, Dale L. Boger, William L. Jorgensen · Journal of the American Chemical Society · 2005 · 179 citations

Macrophomate Synthase:  QM/MM Simulations Address the Diels−Alder versus Michael−Aldol Reaction Mechanism

Cristiano R. W. Guimarães, Marina Udier–Blagović, William L. Jorgensen · Journal of the American Chemical Society · 2005 · 110 citations