Concepedia

Martin N. Horton

MN

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Publications

5

Citations

257

H-Index

5

Active since

1994

Affiliations

Institute of Cancer Research(Current)

Martin N. Horton is an author at Institute of Cancer Research specializing in tumor biology, medicinal chemistry, and breast cancer.

Top concepts

Publications per year

1994–1999

5

Publications

5

Reduced genotoxicity of [D<sub>5</sub>-ethyl]-tamoxifen implicates α-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen

David H. Phillips, Gerard A. Potter, Martin N. Horton et al. · Carcinogenesis · 1994 · 79 citations

Identification of tamoxifen metabolites in human Hep G2 cell line, human liver homogenate, and patients on long-term therapy for breast cancer.

Grace K. Poon, Britta Walter, Per Eystein Lønning et al. · Drug Metabolism and Disposition · 1995 · 74 citations

The deuterium isotope effect for the α-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D<sub>5</sub>-ethyl]tamoxifen

Michael Jarman, Grace K. Poon, Martin Rowlands et al. · Carcinogenesis · 1995 · 54 citations

N-Demethylation accompanies α-hydroxylation in the metabolic activation of tamoxifen in rat liver cells

David H. Phillips, Alan Hewer, Martin N. Horton et al. · Carcinogenesis · 1999 · 31 citations · Full text

Synthesis and DNA Reactivity of α-Hydroxylated Metabolites of Nonsteroidal Antiestrogens

Ian R. Hardcastle, Martin N. Horton, Martin R. Osborne et al. · Chemical Research in Toxicology · 1998 · 19 citations

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