Shuyan Yang

Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.

Stanley B. Prusiner, Darlene Groth, Ana Serban et al. · Proceedings of the National Academy of Sciences · 1993 · 465 citations · Full text

Genetics, Molecular Biology, Protein Expression +16

Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.

Glenn C. Telling, Michael Scott, Karen Hsiao et al. · Proceedings of the National Academy of Sciences · 1994 · 310 citations · Full text

Creutzfeldt-jakob Disease, Transgenic Mouse Models, Genetics +17

Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.

Karen Hsiao, Darlene Groth, Michael Scott et al. · Proceedings of the National Academy of Sciences · 1994 · 282 citations · Full text

Creutzfeldt-jakob Disease, Transgenic Mouse Models, Synaptic Transmission +21

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

Rolf Hecker, Albert Taraboulos, Michael Scott et al. · Genes & Development · 1992 · 209 citations · Full text

Biology, Molecular Neuroscience, Creutzfeldt-jakob Disease +15

Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.

George A. Carlson, C Ebeling, Shuyan Yang et al. · Proceedings of the National Academy of Sciences · 1994 · 153 citations · Full text

Genetics, Prion Isolate, Gene Characterization +18