Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.

Stanley B. Prusiner, Darlene Groth, Ana Serban, +6

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyProtein ExpressionExperimental NeuropathologyPrion Disease +14

Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.

Glenn C. Telling, Michael Scott, Karen Hsiao, +7

Proceedings of the National Academy of Sciences

Creutzfeldt-jakob DiseaseTransgenic Mouse ModelsGeneticsImmunologyChimeric Prp +15

Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.

Karen Hsiao, Darlene Groth, Michael Scott, +7

Proceedings of the National Academy of Sciences

Creutzfeldt-jakob DiseaseTransgenic Mouse ModelsSynaptic TransmissionGeneticsImmunology +19

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

Rolf Hecker, Albert Taraboulos, Michael Scott, +6

Genes & Development

BiologyMolecular NeuroscienceCreutzfeldt-jakob DiseaseMedicineGenetics +13

Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.

George A. Carlson, C Ebeling, Shuyan Yang, +6

Proceedings of the National Academy of Sciences

GeneticsPrion IsolateGene CharacterizationGenomicsTransgenic Mice +16

New retrovirus helper cells with almost no nucleotide sequence homology to retrovirus vectors

Joseph P. Dougherty, Rebecca Wisniewski, Shuyan Yang, +2

Journal of Virology

Viral ReplicationPackaging Cell LinesSynthetic VirologyHuman RetrovirusGenetics +12

Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.

S. J. DeArmond, Shuyan Yang, Anna Lee, +4

Proceedings of the National Academy of Sciences

BiologyCreutzfeldt-jakob DiseaseBiochemistryNatural SciencesGenetics +10

Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28

Yanchao Han, Yu Mu, Xiaoquan Li, +8

Human Molecular Genetics

Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos

Long Zhao, Xinyi Zhao, Tian Tian, +9

Cardiovascular Research

A hybrid nondestructive testing method of pulsed eddy current testing and electromagnetic acoustic transducer techniques based on wavelet analysis

Shejuan Xie, Shuyan Yang, Mingming Tian, +5

NDT & E International

Optical Eddy CurrentElectrical EngineeringEngineeringNondestructive TestingWavelet Analysis +5