Darlene Groth

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

K M Pan, M. A. Baldwin, Jack Nguyen et al. · Proceedings of the National Academy of Sciences · 1993 · 2.3K citations · Full text

Prpsc Synthesis, Protein Chemistry, Protein Secretion +15

Eight prion strains have PrPSc molecules with different conformations

Jiri Safar, Holger Wille, Vincenza Itri et al. · Nature Medicine · 1998 · 1.2K citations

Prion Strains, Structural Biology, Molecular Biology +1

Scrapie prions aggregate to form amyloid-like birefringent rods

Stanley B. Prusiner, Michael P. McKinley, Karen A. Bowman et al. · Cell · 1983 · 1K citations

Alzheimer's Disease, Protein Folding, Prion Disease +5

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

Stanley B. Prusiner, Michael Scott, Dallas Foster et al. · Cell · 1990 · 867 citations

Biology, Transgenetic Studies, Natural Sciences +9

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

Konrad Basler, Bruno Oesch, Michael Scott et al. · Cell · 1986 · 829 citations · Full text

Biology, Chromatin, Cellular Prp Isoforms +11