Linda E. Keown

Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets

F.D. Tattersall, Wayne Rycroft, B. Francis et al. · Neuropharmacology · 1996 · 211 citations

Signal Transduction, Signaling Pathway, Medicine +6

Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance.

Ian Paterson, David Y.‐K. Chen, Mark J. Coster et al. · Angewandte Chemie International Edition · 2001 · 116 citations

Studies in marine macrolide synthesis: Stereocontrolled synthesis of the F-ring subunit of spongistatin 1 (altohyrtin A)

Ian Paterson, Linda E. Keown · Tetrahedron Letters · 1997 · 102 citations

Biosynthesis, Engineering, Biochemistry +8

Total Synthesis of Rhizoxin D, a Potent Antimitotic Agent from the Fungus <i>Rhizopus chinensi</i>s

James D. White, Paul R. Blakemore, Neal J. Green et al. · The Journal of Organic Chemistry · 2002 · 85 citations

<i>N</i>-Heteroaryl-2-phenyl-3-(benzyloxy)piperidines:  A Novel Class of Potent Orally Active Human NK₁ Antagonists

T. Ladduwahetty, R. Baker, Margaret A. Cascieri et al. · Journal of Medicinal Chemistry · 1996 · 66 citations · Full text