Michael L. Pinn

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.

Ellen S. Pizer, Jagan N. Thupari, Wan Fang Han et al. · PubMed · 2000 · 369 citations

Breast Oncology, Chemoprevention Strategy, Fatty-acid Synthase Inhibition +17

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

Eun Kyoung Kim, Ian Miller, Susan Aja et al. · Journal of Biological Chemistry · 2004 · 311 citations · Full text

Nutrition, Reduces Food Intake, Food Intake +16

Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.

Weibo Zhou, P. Jeanette Simpson, Jill M. McFadden et al. · PubMed · 2003 · 218 citations

Apoptosis, Cell Death, S Phase +17

Fatty Acid Synthase Inhibition in Human Breast Cancer Cells Leads to Malonyl-CoA-Induced Inhibition of Fatty Acid Oxidation and Cytotoxicity

Jagan N. Thupari, Michael L. Pinn, Francis P. Kuhajda · Biochemical and Biophysical Research Communications · 2001 · 190 citations

Chemoprevention Strategy, Biochemistry, Medicine +7

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

Patricia M. Alli, Michael L. Pinn, Elizabeth M. Jaffee et al. · Oncogene · 2004 · 163 citations

Breast Oncology, Chemoprevention Strategy, Mammary Gland +8