Wan Fang Han

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.

Ellen S. Pizer, Jagan N. Thupari, Wan Fang Han et al. · PubMed · 2000 · 369 citations

Breast Oncology, Chemoprevention Strategy, Fatty-acid Synthase Inhibition +17

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.

Ellen S. Pizer, Francis J. Chrest, Joseph A. DiGiuseppe et al. · PubMed · 1998 · 250 citations

Chemoprevention Strategy, Apoptosis, Cell Death +16

Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.

Ji Nong Li, Myriam Gorospe, Francis J. Chrest et al. · PubMed · 2001 · 165 citations

Chemoprevention Strategy, Apoptosis, Cell Death +21

Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c

Yixue Yang, Patrice J. Morin, Wan Fang Han et al. · Experimental Cell Research · 2003 · 156 citations

Lipid Synthesis, Biochemistry, Endocrine-related Cancer +5

Fatty Acid Synthase Inhibition Activates AMP-Activated Protein Kinase in SKOV3 Human Ovarian Cancer Cells

Weibo Zhou, Wan Fang Han, Leslie E. Landree et al. · Cancer Research · 2007 · 156 citations · Full text