Francis J. Chrest

Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage

Inna I. Kruman, Robert P. Wersto, Fernando Cardozo‐Pelaez et al. · Neuron · 2004 · 369 citations · Full text

Life Sciences, Cell Biology, Neuroscience +16

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.

Ellen S. Pizer, Jagan N. Thupari, Wan Fang Han et al. · PubMed · 2000 · 369 citations

Life Sciences, Oncology, Pharmacology +17

Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors.

Jürgen Nagel, Rajesh Chopra, Francis J. Chrest et al. · Journal of Clinical Investigation · 1988 · 260 citations · Full text

Life Sciences, Cell Biology, Immunology +14

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.

Ellen S. Pizer, Francis J. Chrest, Joseph A. DiGiuseppe et al. · PubMed · 1998 · 251 citations

Life Sciences, Oncology, Pharmacology +17

Hydrogen-peroxide-induced heme degradation in red blood cells: the protective roles of catalase and glutathione peroxidase

Enika Nagababu, Francis J. Chrest, Joseph M. Rifkind · Biochimica et Biophysica Acta (BBA) - General Subjects · 2003 · 199 citations

Life Sciences, Biochemistry, Physiology +17