Pharmacological Inhibition of AMP-activated Protein Kinase Provides Neuroprotection in Stroke

Louise D. McCullough, Zhiyuan Zeng, Hong Li, +3

Journal of Biological Chemistry

Energy BalanceAmpk ActivityMetabolic RemodelingPharmacological InhibitionSocial Sciences +19

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

Eun Kyoung Kim, Ian Miller, Susan Aja, +6

Journal of Biological Chemistry

NutritionReduces Food IntakeFood IntakeCaloric RestrictionObesity +14

C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity

Jagan N. Thupari, Leslie E. Landree, Gabriele V. Ronnett, +1

Proceedings of the National Academy of Sciences

Fatty Acid Synthase Inhibition Activates AMP-Activated Protein Kinase in SKOV3 Human Ovarian Cancer Cells

Weibo Zhou, Wan Fang Han, Leslie E. Landree, +10

Cancer Research

Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment

Eun Kyoung Kim, Ian Miller, Leslie E. Landree, +8

American Journal of Physiology-Endocrinology and Metabolism

Hypothalamic NeuronsFood IntakeFatty Acid SynthaseHypothalamic CircuitsSocial Sciences +19

C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism

Leslie E. Landree, Andrea L. Hanlon, David W. Strong, +9

Journal of Biological Chemistry

Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro

Amy M. Kleman, J. Yuan, Susan Aja, +2

Journal of Neuroscience Methods

Optimized Neuronal ViabilityNeurophysiologyCellular NeurosciencePhysiological GlucosePhysiology +7

Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight

Susan Aja, Leslie E. Landree, Amy M. Kleman, +13

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

ObesityNutritionMetabolic SyndromeEnergy HomeostasisAppetite Control +13

Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

Francis P. Kuhajda, Susan Aja, Yajun Tu, +10

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Metabolic DisorderFood IntakeGlucose ToleranceInsulin SignalingObesity +17

The connections between C75 and obesity drug-target pathways

Francis P. Kuhajda, Leslie E. Landree, Gabriele V. Ronnett

Trends in Pharmacological Sciences

ObesityMetabolic SyndromeObesity Drug-target PathwaysMedicineObesity Management +4