Huay-Keng Loke

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 457 citations · Full text

Protein Chemistry, Nedd8-amp Mimetic, Protein Function +7

Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

Michael A. Milhollen, Michael P. Thomas, Usha Narayanan et al. · Cancer Cell · 2012 · 108 citations · Full text

Biochemical Genetics, Molecular Biology, Mutagenesis +4

Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues

Jesse J. Chen, Christopher Tsu, James M. Gavin et al. · Journal of Biological Chemistry · 2011 · 92 citations · Full text

Mechanistic Studies, Aldo-keto Reductase, Biochemistry +14

The Tunnel of Acetyl-Coenzyme A Synthase/Carbon Monoxide Dehydrogenase Regulates Delivery of CO to the Active Site

Xiangshi Tan, Huay-Keng Loke, Shawn B. Fitch et al. · Journal of the American Chemical Society · 2005 · 57 citations

Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6

James M. Gavin, Jesse J. Chen, Hua Liao et al. · Journal of Biological Chemistry · 2012 · 40 citations · Full text

Protein Function, Mechanistic Studies, Biochemistry +8