Gordon M. Stott

Zebrafish as a Model Organism for the Identification and Characterization of Drugs and Genes Affecting p53 Signaling

Ulrike Langheinrich, Elisabeth Hennen, Gordon M. Stott et al. · Current Biology · 2002 · 377 citations · Full text

Developmental Biology, Signaling Pathway, Molecular Pathway +7

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

Ganesha Rai, Kyle R. Brimacombe, Bryan T. Mott et al. · Journal of Medicinal Chemistry · 2017 · 146 citations · Full text

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Choh Yeung, Anna E. Gibson, Sameer H. Issaq et al. · Cancer Research · 2019 · 123 citations · Full text

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

Nobu Oshima, Ryo Ishida, Shun Kishimoto et al. · Cell Reports · 2020 · 111 citations · Full text

Dynamic Imaging, Engineering, Oncologic Imaging +13

Discovery of XL413, a potent and selective CDC7 inhibitor

Elena S. Koltun, Amy Lew Tsuhako, David S. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 90 citations · Full text

Medicinal Chemistry, Drug Target, Selective Cdc7 Inhibitor +5