Susan E. Drozda

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

R. Michael Snider, Jay W. Constantine, John Lowe et al. · Science · 1991 · 864 citations

Potent Nonpeptide Antagonist, Biochemistry, Functional Selectivity +12

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 138 citations · Full text

The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine as a novel, nonpeptide substance P antagonist

John Lowe, Susan E. Drozda, R. Michael Snider et al. · Journal of Medicinal Chemistry · 1992 · 107 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Pharmaceutical Chemistry +15

5-Phenyl-3-ureidobenzazepin-2-ones as Cholecystokinin-B Receptor Antagonists

John Lowe, David Hageman, Susan E. Drozda et al. · Journal of Medicinal Chemistry · 1994 · 70 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, 5-Phenyl Group +14

Characterization of Non-peptide Antagonist and Peptide Agonist Binding Sites of the NK1 Receptor with Fluorescent Ligands

Gerardo Turcatti, Sannah Zoffmann, John Lowe et al. · Journal of Biological Chemistry · 1997 · 62 citations · Full text